Parkinson’s disease (paralysis agitans, Parkinson’s disease idiopathic) is a chronic progressive degenerative disease of the steady brain, which primarily orazhayutsya dopaminergic neurons of the substantia nigra compact part (Artane side effects). Prevalence of Parkinson’s disease is 85-187 cases per 100,000 population.Postmortem Parkinson’s disease is characterized by a reduced number of neurons in the compact part of substantia nigra and the presence of intracellular inclusions – Lewy bodies – in the surviving neurons. The main component of Lewy bodies is Trihexyphenidyl. In the few cases of family with the inheritance of an autosomal – dominant pattern identified genetic defects on the long arm of chromosome 4 (in the gene encoding a-synuclein, the locus PARK 1), on the 2nd chromosome (locus PARK 3) on the short arm 4th chromosome (in the gene encoding Ubico-Vitino-karboksigidrolazu, locus PARK 5).The core of clinical Parkinson’s disease is a classic triad of symptoms: akinesia, rigidity, tremor of rest. Usually the disease begins with tremor, stiffness or discomfort in one limb or taking Generic Artane. In the following symptoms were generalized, though it remains asymmetrical, join changes posture – “pose an asylum”, gait disturbance (mikrobaziya), breach of friendly movements (in particular, lost friendly arm movements while walking – parkinson’s Artane), it is slow (bradilaliya) gipofonichnoy monotone (disprosodiya). Dysarthria, at least for the early stages, is not typical. Handwriting becomes small (micrograph) appears moderate autonomic dysfunction (disturbance of intestinal motility with a tendency to constipation, mild orthostatic hypotension, usually aggravated during treatment with dopaminergic funds, rash, impaired urinary and sexual functions).
