Kortikobazalnaya degeneration (CBD) typically manifests itself rapidly progressive asymmetric akinetic-rigid syndrome, resistant to the drug Selegiline. Originally drawn into one of the limbs (usually the hand), which later developed focal dystonia, as well as spontaneous, reflex or induced motion (promotional) myoclonic jerks. Characteristic of Parkinson’s disease tremor of rest is usually absent. Approximately half of patients with a phenomenon «Eldepryl side effects»: when you turn off the visual field (for example, an institution of hands behind his back) the patient is unable to distinguish his injured hand with his good hand of the doctor’s hands. Phenomenon «Eldepryl side effects» often manifested by involuntary movements – arm can, regardless of the patient will go up or bend down, grabbing or groping to make movements, compulsive manipulation of objects – but he can not get her to participate in voluntary movements. In addition to extrapyramidal disorders usually develop focal disorders of higher cortical functions (apraxia, aphasia, astereognosis, grafestezii violation, etc.). In some cases, dementia is not developed until the late stages of the disease, in others – occurs in the early years of the disease. With the involvement of the lower extremities are grossly violated and postural stability of walking. MRI often reveals an asymmetric atrophy with predominant involvement of the posterior temporal and parietal lobes.
Treatment is symptomatic. In some patients the generic Eldepryl reduces manifestations of parkinsonism. To reduce myoclonus used Eldepryl 5mg, when expressed dystonic hyperkinesis, the introduction of botulinum toxin.
